Protection from cisplatin-induced hearing loss with lentiviral vector-mediated ectopic expression of the anti-apoptotic protein BCL-XL

• Main Authors: Larissa Nassauer (Author), Hinrich Staecker (Author), Peixin Huang (Author), Bryan Renslo (Author), Madeleine Goblet (Author), Jennifer Harre (Author), Athanasia Warnecke (Author), Juliane W. Schott (Author), Michael Morgan (Author), Melanie Galla (Author), Axel Schambach (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin is a highly effective chemotherapeutic agent, but it can cause sensorineural hearing loss (SNHL) in patients. Cisplatin-induced ototoxicity is closely related to the accumulation of reactive oxygen species (ROS) and subsequent death of hair cells (HCs) and spiral ganglion neurons (SGNs). D...