Intestinal Ischemia-Reperfusion Increases Efflux for Uric Acid Via Paracellular Route in the Intestine, but Decreases that Via Transcellular Route Mediated by BCRP

• Main Authors: Jiro Ogura (Author), Kaori Kuwayama (Author), Atsushi Takaya (Author), Yusuke Terada (Author), Takashi Tsujimoto (Author), Takahiro Koizumi (Author), Hajime Maruyama (Author), Asuka Fujikawa (Author), Natsuko Takahashi (Author), Masaki Kobayashi (Author), Shirou Itagaki (Author), Takeshi Hirano (Author), Hiroaki Yamaguchi (Author), Ken Iseki (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. Uric acid is thought to be one of the most important antioxidants in human biological fluids. Intestinal ischemia-reperfusion (I/R) is an important factor associated with high rates of morbidity and mortality. Reactive oxygen species (ROS) are responsible for intestinal I/R injury. The aim...