Plateau hypoxia attenuates the metabolic activity of intestinal flora to enhance the bioavailability of nifedipine

• Main Authors: Juanhong Zhang (Author), Yuyan Chen (Author), Yuemei Sun (Author), Rong Wang (Author), Junmin Zhang (Author), Zhengping Jia (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nifedipine is completely absorbed by the gastrointestinal tract and its pharmacokinetics and metabolism may be influenced by microorganisms. If gut microbes are involved in the metabolism of nifedipine, plateau hypoxia may regulate the bioavailability and the therapeutic effect of nifedipine by alte...