Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer

• Main Authors: Yangzom D. Bhutia (Author), Jiro Ogura (Author), Paul J. Grippo (Author), Carolina Torres (Author), Toshihiro Sato (Author), Mitchell Wachtel (Author), Sabarish Ramachandran (Author), Ellappan Babu (Author), Sathish Sivaprakasam (Author), Devaraja Rajasekaran (Author), Bradley Schniers (Author), Nhu On (Author), Logan Smoot (Author), Muthusamy Thangaraju (Author), Jaya P. Gnana-Prakasam (Author), Vadivel Ganapathy (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Based on the evidence that hemochromatosis, an iron-overload disease, drives hepatocellular carcinoma, we hypothesized that chronic exposure to excess iron, either due to genetic or environmental causes, predisposes an individual to cancer. Using pancreatic cancer as our primary focus, we employed c...