Constitutive androstane receptor induced-hepatomegaly and liver regeneration is partially via yes-associated protein activation

• Main Authors: Yue Gao (Author), Shicheng Fan (Author), Hua Li (Author), Yiming Jiang (Author), Xinpeng Yao (Author), Shuguang Zhu (Author), Xiao Yang (Author), Ruimin Wang (Author), Jianing Tian (Author), Frank J. Gonzalez (Author), Min Huang (Author), Huichang Bi (Author)
• Format: Book
• Published: Elsevier, 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The constitutive androstane receptor (CAR, NR3I1) belongs to nuclear receptor superfamily. It was reported that CAR agonist TCPOBOP induces hepatomegaly but the underlying mechanism remains largely unknown. Yes-associated protein (YAP) is a potent regulator of organ size. The aim of this study is to...