The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma

The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma

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It has been shown that melanoma cells do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. Depleting arginine using pegylated arginine deiminase (ADI-PEG20) results in cell death in melanoma but not normal cells. This concept was translat...

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Bibliographic Details
Main Authors: Niramol Savaraj (Author), Chunjing Wu (Author), Marcus Tien Kuo (Author), Min You (Author), Medhi Wangpaichitr (Author), Carlos Robles (Author), Seth Spector (Author), Lynn Feun (Author)
Format: Book
Published: AboutScience Srl, 2007-01-01T00:00:00Z.
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