The Relationship of Arginine Deprivation, Argininosuccinate Synthetase and Cell Death in Melanoma
It has been shown that melanoma cells do not express argininosuccinate synthetase (ASS) and therefore are unable to synthesize arginine from citrulline. Depleting arginine using pegylated arginine deiminase (ADI-PEG20) results in cell death in melanoma but not normal cells. This concept was translat...
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