Oral Administration of Glutathione Trisulfide Increases Reactive Sulfur Levels in Dorsal Root Ganglion and Ameliorates Paclitaxel-Induced Peripheral Neuropathy in Mice

• Main Authors: Mariko Ezaka (Author), Eizo Marutani (Author), Yusuke Miyazaki (Author), Eiki Kanemaru (Author), Martin K. Selig (Author), Sophie L. Boerboom (Author), Katrina F. Ostrom (Author), Anat Stemmer-Rachamimov (Author), Donald B. Bloch (Author), Gary J. Brenner (Author), Etsuo Ohshima (Author), Fumito Ichinose (Author)
• Format: Book
• Published: MDPI AG, 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peripheral neuropathy is a dose-limiting side effect of chemotherapy with paclitaxel. Paclitaxel-induced peripheral neuropathy (PIPN) is typically characterized by a predominantly sensory neuropathy presenting with allodynia, hyperalgesia and spontaneous pain. Oxidative mitochondrial damage in perip...