Rheb-mTOR activation rescues Aβ-induced cognitive impairment and memory function by restoring miR-146 activity in glial cells

• Main Authors: Dipayan De (Author), Ishita Mukherjee (Author), Subhalakshmi Guha (Author), Ramesh Kumar Paidi (Author), Saikat Chakrabarti (Author), Subhas C. Biswas (Author), Suvendra N. Bhattacharyya (Author)
• Format: Book
• Published: Elsevier, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Deposition of amyloid beta plaques in adult rat or human brain is associated with increased production of proinflammatory cytokines by associated glial cells that are responsible for degeneration of the diseased tissue. The expression of these cytokines is usually under check and is controlled at th...