Bacterial Lipopolysaccharide Increases Serotonin Metabolism in Both Medial Prefrontal Cortex and Nucleus Accumbens in Male Wild Type Rats, but Not in Serotonin Transporter Knockout Rats

• Main Authors: Gerdien A. H. Korte-Bouws (Author), Floor van Heesch (Author), Koen G. C. Westphal (Author), Lisa M. J. Ankersmit (Author), Edwin M. van Oosten (Author), Onur Güntürkün (Author), S. Mechiel Korte (Author)
• Format: Book
• Published: MDPI AG, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

It is well known that bacterial lipopolysaccharides (LPS) both increases proinflammatory cytokines and produces sickness behavior, including fatigue and anhedonia (i.e., the inability to experience pleasure). Previously, we have shown that intraperitoneally (i.p.) administered LPS increased extracel...