RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer

• Main Authors: Xinbing Sui (Author), Ruonan Zhang (Author), Shuiping Liu (Author), Ting Duan (Author), Lijuan Zhai (Author), Mingming Zhang (Author), Xuemeng Han (Author), Yu Xiang (Author), Xingxing Huang (Author), Haoming Lin (Author), Tian Xie (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ferroptosis is an iron-dependent, oxidative cell death, and is characterized by iron-dependent accumulation of reactive oxygen species (ROS) within the cell. It has been implicated in various human diseases, including cancer. Recently, ferroptosis, as a non-apoptotic form of cell death, is emerging...