Irf5 siRNA-loaded biodegradable lipid nanoparticles ameliorate concanavalin A-induced liver injury

• Main Authors: Wataru Kawase (Author), Daisuke Kurotaki (Author), Yuta Suzuki (Author), Hiroshi Ishihara (Author), Tatsuma Ban (Author), Go R. Sato (Author), Juri Ichikawa (Author), Hideyuki Yanai (Author), Tadatsugu Taniguchi (Author), Kappei Tsukahara (Author), Tomohiko Tamura (Author)
• Format: Book
• Published: Elsevier, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

RNA interference-based gene silencing drugs are attracting attention for treating various diseases. Lipid nanoparticles (LNPs) are carriers that efficiently deliver small interfering RNA (siRNA) to the cytoplasm of target cells. Recently, we developed potent and well-tolerated biodegradable LNPs wit...