Pharmacokinetically guided dosing of oral sorafenib in pediatric hepatocellular carcinoma: A simulation study

• Main Authors: John C. Panetta (Author), Olivia Campagne (Author), Jessica Gartrell (Author), Wayne Furman (Author), Clinton F. Stewart (Author)
• Formato: Livro
• Publicado em: Wiley, 2021-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Sorafenib improves outcomes in adult hepatocellular carcinoma; however, hand foot skin reaction (HFSR) is a dose limiting toxicity of sorafenib that limits its use. HFSR has been associated with sorafenib systemic exposure. The objective of this study was to use modeling and simulation to d...