Quantification of Fosfomycin in Combination with Nine Antibiotics in Human Plasma and Cation-Adjusted Mueller-Hinton II Broth via LCMS

• Main Authors: Kelvin Kau-Kiat Goh (Author), Wilson Ghim-Hon Toh (Author), Daryl Kim-Hor Hee (Author), Edwin Zhi-Wei Ting (Author), Nathalie Grace Sy Chua (Author), Farah Iffah Binte Zulkifli (Author), Li-Jiao Sin (Author), Thuan-Tong Tan (Author), Andrea Lay-Hoon Kwa (Author), Tze-Peng Lim (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Fosfomycin-based combination therapy has emerged as an attractive option in our armamentarium due to its synergistic activity against carbapenem-resistant Gram-negative bacteria (CRGNB). The ability to simultaneously measure fosfomycin and other antibiotic drug levels will support in vitro and clini...