Heparin chromatography as an in vitro predictor for antibody clearance rate through pinocytosis

• Main Authors: Thomas E. Kraft (Author), Wolfgang F. Richter (Author), Thomas Emrich (Author), Alexander Knaupp (Author), Michaela Schuster (Author), Andreas Wolfert (Author), Hubert Kettenberger (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The pharmacokinetic (PK) properties of therapeutic antibodies directly affect efficacy, dose and dose intervals, application route and tissue penetration. In indications where health-care providers and patients can choose between several efficacious and safe therapeutic options, convenience (determi...