Endothelial and inflammatory pathophysiology in dengue shock: New insights from a prospective cohort study in Vietnam.

• Main Authors: Angela McBride (Author), Huynh Thi Le Duyen (Author), Nguyen Lam Vuong (Author), Phan Vinh Tho (Author), Luong Thi Hue Tai (Author), Nguyen Thanh Phong (Author), Nguyen Thanh Ngoc (Author), Lam Minh Yen (Author), Phung Tran Huy Nhat (Author), Tran Thuy Vi (Author), Martin J Llewelyn (Author), Louise Thwaites (Author), Nguyen Van Hao (Author), Sophie Yacoub (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dengue shock (DS) is the most severe complication of dengue infection; endothelial hyperpermeability leads to profound plasma leakage, hypovolaemia and extravascular fluid accumulation. At present, the only treatment is supportive with intravenous fluid, but targeted endothelial stabilising therapie...