Structure-Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels

• Huvudskapare: Fernanda C. Cardoso (Författare, medförfattare), Richard J. Lewis (Författare, medförfattare)
• Materialtyp: Bok
• Publicerad: Frontiers Media S.A., 2019-04-01T00:00:00Z.
• Ämnen: article
• Länkar: Connect to this object online.

Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that exhibit unique pharmacological properties to modulate key membrane protein targets. Voltage-gated sodium channels (NaV) are often targeted by these peptides to allosterically promote opening or closing of the chan...