Regulatory T cells enhance susceptibility to experimental Trypanosoma congolense infection independent of mouse genetic background.

• Main Authors: Ifeoma Okwor (Author), Chukwunonso Onyilagha (Author), Shiby Kuriakose (Author), Zhirong Mou (Author), Ping Jia (Author), Jude E Uzonna (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND: BALB/c mice are highly susceptible while C57BL/6 are relatively resistant to experimental Trypanosoma congolense infection. Although regulatory T cells (Tregs) have been shown to regulate the pathogenesis of experimental T. congolense infection, their exact role remains controversial. We...