PEG-Free Polyion Complex Nanocarriers for Brain-Derived Neurotrophic Factor

• Egile Nagusiak: James M. Fay (Egilea), Chaemin Lim (Egilea), Anna Finkelstein (Egilea), Elena V. Batrakova (Egilea), Alexander V. Kabanov (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2022-06-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Many therapeutic formulations incorporate poly(ethylene glycol) (PEG) as a stealth component to minimize early clearance. However, PEG is immunogenic and susceptible to accelerated clearance after multiple administrations. Here, we present two novel reformulations of a polyion complex (PIC), origina...