Gating Properties of Mutant Sodium Channels and Responses to Sodium Current Inhibitors Predict Mexiletine-Sensitive Mutations of Long QT Syndrome 3

• Main Authors: Gang Li (Author), Ryan L. Woltz (Author), Cheng-yu Wang (Author), Lu Ren (Author), Pei-xin He (Author), Shan-dong Yu (Author), Xue-qin Liu (Author), Vladimir Yarov-Yarovoy (Author), Dan Hu (Author), Nipavan Chiamvimonvat (Author), Lin Wu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundLong QT syndrome 3 (LQT3) is caused by SCN5A mutations. Late sodium current (late INa) inhibitors are current-specific to treat patients with LQT3, but the mechanisms underlying mexiletine (MEX) -sensitive (N1325S and R1623Q) and -insensitive (M1652R) mutations remains to be elucidated.Met...