Pharmacokinetics, Urinary Excretion, and Pharmaco-Metabolomic Study of Tebipenem Pivoxil Granules After Single Escalating Oral Dose in Healthy Chinese Volunteers

• Main Authors: Zeyun Li (Author), Mei Su (Author), Weiyan Cheng (Author), Jueyu Xia (Author), Shuaibing Liu (Author), Ruijuan Liu (Author), Suke Sun (Author), Luyao Feng (Author), Xueya Zhu (Author), Xiaojian Zhang (Author), Xin Tian (Author), Lingbo Qu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tebipenem pivoxil (TBPM-PI), an oral carbapenem antibiotic, has shown special advantages in pediatric infections and was in urgent need in China. Although pharmacokinetics, urinary excretion, and metabolite information of its active form tebipenem (TBPM) has been reported, ethnic differences may exi...