Development and Evaluation of EDTA-Treated Rabbits for Bioavailability Study of Chelating Drugs Using Levofloxacin, Ciprofloxacin, Hemiacetal Ester Prodrugs, and Tetracycline

• Main Authors: Yorinobu Maeda (Author), Honoka Teraoka (Author), Ami Okada (Author), Mirei Yamamoto (Author), Shintaro Natsuyama (Author), Yuhzo Hieda (Author), Yuka Nagatsuka (Author), Yuhki Sato (Author), Takeshi Goromaru (Author), Teruo Murakami (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Laboratory rabbits are fed foods rich with cationic metals, and while fasting cannot empty gastric contents because of their coprophagic habits. This implies that, in rabbits, the oral bioavailability of chelating drugs could be modulated by the slow gastric emptying rates and the interaction (chela...