RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling

• Main Authors: Jirong Wang (Author), Chengyun Xu (Author), Jing Zhang (Author), Yizhong Bao (Author), Ying Tang (Author), Xiaoling Lv (Author), Bo Ma (Author), Ximei Wu (Author), Genxiang Mao (Author)
• Format: Book
• Published: BMC, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The cytoskeletal architecture of osteoclasts (OCs) and bone resorption activity must be appropriately controlled for proper bone remodeling, which is associated with osteoporosis. The RhoA protein of GTPase plays a regulatory role in cytoskeletal components and contributes to ost...