Latency, thermal stability, and identification of an inhibitory compound of mirolysin, a secretory protease of the human periodontopathogen Tannerella forsythia

• मुख्य लेखकों: Krzysztof M. Zak (लेखक), Mark J. Bostock (लेखक), Irena Waligorska (लेखक), Ida B. Thøgersen (लेखक), Jan J. Enghild (लेखक), Grzegorz M. Popowicz (लेखक), Przemyslaw Grudnik (लेखक), Jan Potempa (लेखक), Miroslaw Ksiazek (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Mirolysin is a secretory protease of Tannerella forsythia, a member of the dysbiotic oral microbiota responsible for periodontitis. In this study, we show that mirolysin latency is achieved by a "cysteine-switch" mechanism exerted by Cys23 in the N-terminal profragment. Mutation of Cys23 s...