Positive allosteric modulation of mGluR5 accelerates extinction learning but not relearning following methamphetamine self-administration

• Main Authors: Peter R Kufahl (Author), Lauren E Hood (Author), Natali E Nemirovsky (Author), Piroska eBarabas (Author), Casey eHalstengard (Author), Angel eVilla (Author), Elisabeth eMoore (Author), Lucas R Watterson (Author), M Foster eOlive (Author)
• Format: Book
• Published: Frontiers Media S.A., 2012-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Recent studies have implicated glutamate neurotransmission as an important substrate for the extinction of conditioned behaviors, including responding for drug reinforcement. Positive allosteric modulation of the type-5 metabotropic glutamate receptor (mGluR5) in particular has emerged as a treatmen...