Optimized In Vivo Transfer of Small Interfering RNA Targeting Dermal Tissue Using In Vivo Surface Electroporation

• Main Authors: Kate E Broderick (Author), Amy Chan (Author), Feng Lin (Author), Xuefei Shen (Author), Gleb Kichaev (Author), Amir S Khan (Author), Justin Aubin (Author), Tracy S Zimmermann (Author), Niranjan Y. Sardesai (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Electroporation (EP) of mammalian tissue is a technique that has been used successfully in the clinic for the delivery of genetic-based vaccines in the form of DNA plasmids. There is great interest in platforms which efficiently deliver RNA molecules such as messenger RNA and small interfering RNA (...