Glucose Activates Lysine-Specific Demethylase 1 through the KEAP1/p62 Pathway

• Main Authors: Chiao-Yun Lin (Author), Chen-Bin Chang (Author), Ren-Chin Wu (Author), Angel Chao (Author), Yun-Shien Lee (Author), Chi-Neu Tsai (Author), Chih-Hao Chen (Author), Chih-Feng Yen (Author), Chia-Lung Tsai (Author)
• Format: Book
• Published: MDPI AG, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endometrial cancer incidence increases annually. Several risk factors, including high glucose intake, are associated with endometrial cancer. We investigated whether glucose affects lysine-specific demethylase 1 (LSD1) expression and the responsible molecular mechanisms. A high concentration of gluc...