PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats

• Main Authors: Ya Zhao (Author), Yanwei Wang (Author), Yuying Wu (Author), Cimin Tao (Author), Rui Xu (Author), Yong Chen (Author), Linghui Qian (Author), Tengfei Xu (Author), Xiaoyuan Lian (Author)
• Format: Book
• Published: Elsevier, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Epidemiological and animal studies indicate that pre-existing diabetes increases the risk of Parkinson's disease (PD). However, the mechanisms underlying this association remain unclear. In the present study, we found that high glucose (HG) levels in the cerebrospinal fluid (CSF) of diabetic ra...