No Effect of Digoxin on Rosuvastatin Pharmacokinetics in Healthy Subjects: Utility of Oita Combination for Clinical Drug-Drug Interaction Study

• Main Authors: Naoyuki Otani (Author), Hirokazu Wakuda (Author), Hiromitsu Imai (Author), Masae Kuranari (Author), Yasuyuki Ishii (Author), Yuko Ito (Author), Akihiro Okubo (Author), Osamu Ogawa (Author), Kenji Takeda (Author), Tetsuji Ohyama (Author), Tomoko Hasunuma (Author), Naoto Uemura (Author)
• Format: Book
• Published: Wiley, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study evaluated the utility of combination of digoxin (0.25 mg) and rosuvastatin (5 mg) as a new transporter (P‐glycoprotein/breast cancer resistance protein/organic anion‐transporting polypeptide (OATP)1B1/OATP1B3) probe cocktail (Oita combination) for drug-drug interaction (DDI) studies by de...