In vitro and in vivo analyses of eFAP: a novel FAP-targeting small molecule for radionuclide theranostics and other oncological interventions

• Main Authors: Circe D. van der Heide (Author), Hanyue Ma (Author), Mark W.H. Hoorens (Author), Joana D. Campeiro (Author), Debra C. Stuurman (Author), Corrina M.A. de Ridder (Author), Yann Seimbille (Author), Simone U. Dalm (Author)
• Format: Book
• Published: SpringerOpen, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Fibroblast activation protein (FAP), a transmembrane serine protease overexpressed by cancer-associated fibroblasts in the tumor stroma, is an interesting biomarker for targeted radionuclide theranostics. FAP-targeting radiotracers have demonstrated to be superior to [18F]FDG PET...