PARP-1 Is Critical for Recruitment of Dendritic Cells to the Lung in a Mouse Model of Asthma but Dispensable for Their Differentiation and Function

• Main Authors: Laura C. Echeverri Tirado (Author), Mohamed A. Ghonim (Author), Jeffrey Wang (Author), Amir A. Al-Khami (Author), Dorota Wyczechowska (Author), Hanh H. Luu (Author), Hogyoung Kim (Author), Maria Dulfary Sanchez-Pino (Author), José Yélamos (Author), Lina M. Yassin (Author), A. Hamid Boulares (Author)
• Format: Book
• Published: Hindawi Limited, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Dendritic cells (DCs) are critical in asthma and many other immune diseases. We previously demonstrated a role for PARP-1 in asthma. Evidence on PARP-1 playing a role in Th2-associated DC function is not clear. In this study, we examined whether PARP-1 is critical for DC differentiation and function...