Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo

• Asıl Yazarlar: Mark W. Dodson (Yazar), Lok K. Leung (Yazar), Mohiddin Lone (Yazar), Michael A. Lizzio (Yazar), Ming Guo (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: The Company of Biologists, 2014-12-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Mutations in LRRK2 cause a dominantly inherited form of Parkinson's disease (PD) and are the most common known genetic determinant of PD. Inhibitor-based therapies targeting LRRK2 have emerged as a key therapeutic strategy in PD; thus, understanding the consequences of inhibiting the normal cel...