Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo

Mutations in LRRK2 cause a dominantly inherited form of Parkinson's disease (PD) and are the most common known genetic determinant of PD. Inhibitor-based therapies targeting LRRK2 have emerged as a key therapeutic strategy in PD; thus, understanding the consequences of inhibiting the normal cel...

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Asıl Yazarlar: Mark W. Dodson (Yazar), Lok K. Leung (Yazar), Mohiddin Lone (Yazar), Michael A. Lizzio (Yazar), Ming Guo (Yazar)
Materyal Türü: Kitap
Baskı/Yayın Bilgisi: The Company of Biologists, 2014-12-01T00:00:00Z.
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3rd Floor Main Library

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Yer Numarası: A1234.567
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