Novel ethyl methanesulfonate (EMS)-induced null alleles of the Drosophila homolog of LRRK2 reveal a crucial role in endolysosomal functions and autophagy in vivo

• 主要な著者: Mark W. Dodson (著者), Lok K. Leung (著者), Mohiddin Lone (著者), Michael A. Lizzio (著者), Ming Guo (著者)
• フォーマット: 図書
• 出版事項: The Company of Biologists, 2014-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Mutations in LRRK2 cause a dominantly inherited form of Parkinson's disease (PD) and are the most common known genetic determinant of PD. Inhibitor-based therapies targeting LRRK2 have emerged as a key therapeutic strategy in PD; thus, understanding the consequences of inhibiting the normal cel...