CRISPR knockdown of Kcnq3 attenuates the M-current and increases excitability of NPY/AgRP neurons to alter energy balance

• Main Authors: Todd L. Stincic (Author), Martha A. Bosch (Author), Avery C. Hunker (Author), Barbara Juarez (Author), Ashley M. Connors (Author), Larry S. Zweifel (Author), Oline K. Rønnekleiv (Author), Martin J. Kelly (Author)
• Format: Book
• Published: Elsevier, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Arcuate nucleus neuropeptide Y/agouti-related peptide (NPY/AgRP) neurons drive ingestive behavior. The M-current, a subthreshold non-inactivating potassium current, plays a critical role in regulating NPY/AgRP neuronal excitability. Fasting decreases while 17β-estradiol increases the M-cu...