N,N-Dimethyl-D-erythro-Sphingosine Inhibits Store-Operated Ca2+ Entry in U937 Monocytes

• Main Authors: Ji-Yeong Jo (Author), Hyo-Lim Kim (Author), Yun-Kyung Lee (Author), Hideaki Tomura (Author), Yoe-Sik Bae (Author), Fumikazu Okajima (Author), Dong-Soon Im (Author)
• Format: Book
• Published: Elsevier, 2008-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Calcium is a ubiquitous second messenger that controls a broad range of cellular functions, and store-operated calcium entry (SOCE) is the primary mechanism of regulated Ca2+ entry in non-excitable immunocytes. In this study, we found that N,N-dimethyl-D-erythro-sphingosine (DMS) inhibited SOCE. In...