Inhibition of Agonist-Induced Positive Inotropy by a Selective Rho-Associated Kinase Inhibitor, Y-27632

We examined the effect of Y-27632 ((+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclo-hexanecarboxamide), a selective Rho-associated kinase (ROCK) inhibitor, on agonist-induced inotropy in isolated mouse left atria. Endothelin-1, angiotensin-II, and prostaglandin F2α (PGF2α) produced positive inotrop...

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Main Authors: Kazuhide Nishimaru (Author), Yoshio Tanaka (Author), Hikaru Tanaka (Author), Koki Shigenobu (Author)
Format: Book
Published: Elsevier, 2003-01-01T00:00:00Z.
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Call Number: A1234.567
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