Inhibition of Agonist-Induced Positive Inotropy by a Selective Rho-Associated Kinase Inhibitor, Y-27632

• Main Authors: Kazuhide Nishimaru (Author), Yoshio Tanaka (Author), Hikaru Tanaka (Author), Koki Shigenobu (Author)
• 格式: 圖書
• 出版: Elsevier, 2003-01-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

We examined the effect of Y-27632 ((+)-(R)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cyclo-hexanecarboxamide), a selective Rho-associated kinase (ROCK) inhibitor, on agonist-induced inotropy in isolated mouse left atria. Endothelin-1, angiotensin-II, and prostaglandin F2α (PGF2α) produced positive inotrop...