Immunological Aspects of X-Linked Chronic Granulomatous Disease Female Carriers

• Main Authors: Maria Chiriaco (Author), Irene Salfa (Author), Giorgiana Madalina Ursu (Author), Cristina Cifaldi (Author), Silvia Di Cesare (Author), Paolo Rossi (Author), Gigliola Di Matteo (Author), Andrea Finocchi (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

X-linked Granulomatous Disease (XL-CGD) carriers were previously thought to be clinically healthy because random X-chromosome inactivation (XCI) allows approximately half of their phagocytes/monocytes to express functional gp91phox protein. This supports the NADPH oxidase activity necessary for the...