The role of s-palmitoylation in neurological diseases: implication for zDHHC family
S-palmitoylation is a reversible posttranslational modification, and the palmitoylation reaction in human-derived cells is mediated by the zDHHC family, which is composed of S-acyltransferase enzymes that possess the DHHC (Asp-His-His-Cys) structural domain. zDHHC proteins form an autoacylation inte...
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| Format: | Book |
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Frontiers Media S.A.,
2024-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_fb128b4c5a4c44d4a09f77fed2cf707d | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Dan Liao |e author |
| 700 | 1 | 0 | |a Yutao Huang |e author |
| 700 | 1 | 0 | |a Dan Liu |e author |
| 700 | 1 | 0 | |a Dan Liu |e author |
| 700 | 1 | 0 | |a Haofuzi Zhang |e author |
| 700 | 1 | 0 | |a Xinyu Shi |e author |
| 700 | 1 | 0 | |a Xin Li |e author |
| 700 | 1 | 0 | |a Peng Luo |e author |
| 245 | 0 | 0 | |a The role of s-palmitoylation in neurological diseases: implication for zDHHC family |
| 260 | |b Frontiers Media S.A., |c 2024-01-01T00:00:00Z. | ||
| 500 | |a 1663-9812 | ||
| 500 | |a 10.3389/fphar.2023.1342830 | ||
| 520 | |a S-palmitoylation is a reversible posttranslational modification, and the palmitoylation reaction in human-derived cells is mediated by the zDHHC family, which is composed of S-acyltransferase enzymes that possess the DHHC (Asp-His-His-Cys) structural domain. zDHHC proteins form an autoacylation intermediate, which then attaches the fatty acid to cysteine a residue in the target protein. zDHHC proteins sublocalize in different neuronal structures and exert dif-ferential effects on neurons. In humans, many zDHHC proteins are closely related to human neu-rological disor-ders. This review focuses on a variety of neurological disorders, such as AD (Alz-heimer's disease), HD (Huntington's disease), SCZ (schizophrenia), XLID (X-linked intellectual disability), attention deficit hyperactivity disorder and glioma. In this paper, we will discuss and summarize the research progress regarding the role of zDHHC proteins in these neu-rological disorders. | ||
| 546 | |a EN | ||
| 690 | |a S-palmitoylation | ||
| 690 | |a protein acyltransferase | ||
| 690 | |a zDHHC | ||
| 690 | |a glutamate receptor | ||
| 690 | |a scaffold protein | ||
| 690 | |a neurological diseases | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Frontiers in Pharmacology, Vol 14 (2024) | |
| 787 | 0 | |n https://www.frontiersin.org/articles/10.3389/fphar.2023.1342830/full | |
| 787 | 0 | |n https://doaj.org/toc/1663-9812 | |
| 856 | 4 | 1 | |u https://doaj.org/article/fb128b4c5a4c44d4a09f77fed2cf707d |z Connect to this object online. |