Paneth-cell-disruption-induced necrotizing enterocolitis in mice requires live bacteria and occurs independently of TLR4 signaling

• Główni autorzy: Jessica R. White (Autor), Huiyu Gong (Autor), Brock Pope (Autor), Patrick Schlievert (Autor), Steven J. McElroy (Autor)
• Format: Książka
• Wydane: The Company of Biologists, 2017-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Necrotizing enterocolitis (NEC) remains a leading cause of morbidity and mortality in premature infants. Both human surgical specimens and animal models suggest a potential involvement of Paneth cells in NEC pathogenesis. Paneth cells play critical roles in epithelial homeostasis, innate immunity an...