Computer-assisted drug discovery (CADD) of an anti-cancer derivative of the theobromine alkaloid inhibiting VEGFR-2

• Main Authors: Ibrahim H. Eissa (Author), Reda G. Yousef (Author), Mostafa A. Asmaey (Author), Hazem Elkady (Author), Dalal Z. Husein (Author), Aisha A. Alsfouk (Author), Ibrahim M. Ibrahim (Author), Mohamed A. Elkady (Author), Eslam B. Elkaeed (Author), Ahmed M. Metwaly (Author)
• Format: Book
• Published: Elsevier, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

VEGFR-2 is a significant target in cancer treatment, inhibiting angiogenesis and impeding tumor growth. Utilizing the essential pharmacophoric structural properties, a new semi-synthetic theobromine analogue (T-1-MBHEPA) was designed as VEGFR-2 inhibitor. Firstly, T-1-MBHEPA's stability and rea...