Diminished ketone interconversion, hepatic TCA cycle flux, and glucose production in D-β-hydroxybutyrate dehydrogenase hepatocyte-deficient mice

• Main Authors: David B. Stagg (Author), Jacob R. Gillingham (Author), Alisa B. Nelson (Author), Justin E. Lengfeld (Author), D. André d'Avignon (Author), Patrycja Puchalska (Author), Peter A. Crawford (Author)
• Format: Book
• Published: Elsevier, 2021-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Throughout the last decade, interest has intensified in intermittent fasting, ketogenic diets, and exogenous ketone therapies as prospective health-promoting, therapeutic, and performance-enhancing agents. However, the regulatory roles of ketogenesis and ketone metabolism on liver homeost...