Progressive Sub-MIC Exposure of <i>Klebsiella pneumoniae</i> 43816 to Cephalothin Induces the Evolution of Beta-Lactam Resistance without Acquisition of Beta-Lactamase Genes

• Main Authors: Jasmine R. Anderson (Author), Nghi B. Lam (Author), Jazmyne L. Jackson (Author), Sean M. Dorenkott (Author), Taylor Ticer (Author), Emir Maldosevic (Author), Amanda Velez (Author), Megan R. Camden (Author), Terri N. Ellis (Author)
• Format: Book
• Published: MDPI AG, 2023-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Bacterial exposure to antibiotic concentrations below the minimum inhibitory concentration (MIC) may result in a selection window allowing for the rapid evolution of resistance. These sub-MIC concentrations are commonly found in soils and water supplies in the greater environment. This study aimed t...