11-amino acid peptide imitating the structure of erythropoietin α-helix b improves endothelial function, but stimulates thrombosis in rats.

• Main Authors: M. V. Korokin (Author), V. O. Soldatov (Author), A. A. Tietze (Author), M. V. Golubev (Author), A. E. Belykh (Author), M. V. Kubekina (Author), O. A. Puchenkova (Author), T. A. Denisyuk (Author), V. V. Gureyev (Author), T. G. Pokrovskaya (Author), O. S. Gudyrev (Author), M. A. Zhuchenko (Author), M. A. Zatolokina (Author), M. V. Pokrovskiy (Author)
• Format: Book
• Published: Volgograd State Medical University, Pyatigorsk Medical and Pharmaceutical Institute, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of the study was to test whether P-αB can be positioned as a preventing and treating agent for cardiovascular diseases.Materials and methods. The study was performed on sexually mature male Wistar rats. Endothelial dysfunction was modulated by a 7-days intraperitoneal administration of L-NAM...