Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA

• Main Authors: Sonia Golombek (Author), Thomas Hoffmann (Author), Ludmilla Hann (Author), Markus Mandler (Author), Sabine Schmidhuber (Author), Josefin Weber (Author), Young-Tae Chang (Author), Roman Mehling (Author), Andrea Ladinig (Author), Christian Knecht (Author), Johanna Leyens (Author), Christian Schlensak (Author), Hans Peter Wendel (Author), Achim Schneeberger (Author), Meltem Avci-Adali (Author)
• Format: Book
• Published: Elsevier, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this study, de novo tropoelastin (TE) synthesis is investigated in vitro and in vivo using different TE-encoding synthetic mRNA variants after codon optimization and nucleotide modification. Codon optimization...