A Selective Thromboxane A2 (TXA2) Synthase Inhibitor, Ozagrel, Attenuates Lung Injury and Decreases Monocyte Chemoattractant Protein-1 and Interleukin-8 mRNA Expression in Oleic Acid-Induced Lung Injury in Guinea Pigs

• Main Authors: Yoichi Ishitsuka (Author), Hiroshi Moriuchi (Author), Yoichiro Isohama (Author), Hidehiro Tokunaga (Author), Keita Hatamoto (Author), Sumika Kurita (Author), Mitsuru Irikura (Author), Ken-ichi Iyama (Author), Tetsumi Irie (Author)
• Format: Book
• Published: Elsevier, 2009-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

This study examined the effect of ozagrel, a thromboxane A2 synthase inhibitor, on the accumulation of leucocytes and chemokine mRNA expression in lungs experimentally injured using oleic acid (OA). OA injection into guinea pigs rapidly increased thromboxane A2 generation and subsequently increased...