Physiologically‐based pharmacokinetic modeling of dextromethorphan to investigate interindividual variability within CYP2D6 activity score groups
Abstract This study provides a whole‐body physiologically‐based pharmacokinetic (PBPK) model of dextromethorphan and its metabolites dextrorphan and dextrorphan O‐glucuronide for predicting the effects of cytochrome P450 2D6 (CYP2D6) drug‐gene interactions (DGIs) on dextromethorphan pharmacokinetics...
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| Main Authors: | , , , , |
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| Format: | Book |
| Published: |
Wiley,
2022-04-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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