Evaluation of transgene expression characteristics and DNA vaccination against melanoma metastasis of an intravenously injected ternary complex with biodegradable dendrigraft poly-L-lysine in mice

• Main Authors: Yukinobu Kodama (Author), Ayako Tokunaga (Author), Junya Hashizume (Author), Hiroo Nakagawa (Author), Hitomi Harasawa (Author), Tomoaki Kurosaki (Author), Tadahiro Nakamura (Author), Koyo Nishida (Author), Mikiro Nakashima (Author), Mitsuru Hashida (Author), Shigeru Kawakami (Author), Hitoshi Sasaki (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We developed a biocompatible splenic vector for a DNA vaccine against melanoma. The splenic vector is a ternary complex composed of plasmid DNA (pDNA), biodegradable dendrigraft poly-L-lysine (DGL), and γ-polyglutamic acid (γ-PGA), the selective uptake of which by the spleen has already been demonst...