Farnesyl Transferase Inhibitor Lonafarnib Enhances α7nAChR Expression Through Inhibiting DNA Methylation of CHRNA7 and Increases α7nAChR Membrane Trafficking

• Auteurs principaux: Tingting Chen (Auteur), Chengyun Cai (Auteur), Lifeng Wang (Auteur), Shixin Li (Auteur), Ling Chen (Auteur)
• Format: Livre
• Publié: Frontiers Media S.A., 2020-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Inhibition of Ras farnesylation in acute has been found to upregulate the α7 nicotinic acetylcholine receptor (α7nAChR) activity. This study was carried out to investigate the effect of chronic administration for 7 days of farnesyl transferase inhibitor lonafarnib (50 mg/kg, intraperitoneally inject...