Activation of PXR by Alpinetin Contributes to Abrogate Chemically Induced Inflammatory Bowel Disease

• Main Authors: Zhilun Yu (Author), Bei Yue (Author), Lili Ding (Author), Xiaoping Luo (Author), Yijing Ren (Author), Jingjing Zhang (Author), Sridhar Mani (Author), Zhengtao Wang (Author), Wei Dou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Alpinetin is a naturally occurring flavonoid from the ginger plants. We previously reported the identification of alpinetin as a ligand of human pregnane X receptor (hPXR). The current study investigated the role of alpinetin as a putative PXR activator in ameliorating chemically induced inflammator...