Pd(II) and Pt(II) Trinuclear Chelates with Spermidine: Selective Anticancer Activity towards TNBC-Sensitive and -Resistant to Cisplatin

• Main Authors: Martin Vojtek (Author), Clara B. Martins (Author), Raquel Ramos (Author), Sara Gomes Duarte (Author), Isabel M. P. L. V. O. Ferreira (Author), Ana L. M. Batista de Carvalho (Author), M. Paula M. Marques (Author), Carmen Diniz (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer and constitutes 10-20% of all breast cancer cases. Even though platinum-based drugs such as cisplatin and carboplatin are effective in TNBC patients, their toxicity and development of cancer drug resistance oft...