Identification of ethyl pyruvate as a NLRP3 inflammasome inhibitor that preserves mitochondrial integrity

• Main Authors: Sujun Li (Author), Fang Liang (Author), Kevin Kwan (Author), Yiting Tang (Author), Xiangyu Wang (Author), Youzhou Tang (Author), Jianhua Li (Author), Huan Yang (Author), Sangeeta S. Chavan (Author), Haichao Wang (Author), Ulf Andersson (Author), Ben Lu (Author), Kevin J. Tracey (Author)
• Format: Book
• Published: BMC, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background The NLRP3 inflammasome, a cytosolic complex that mediates the maturation of IL-1β and IL-18 as well as the release of high mobility group box 1 (HMGB1), contributes to the lethality of endotoxic shock. Ethyl pyruvate (EP) was previously shown to inhibit HMGB1 release and promote...