Lineage-dependent differences in the disease progression of Zika virus infection in type-I interferon receptor knockout (A129) mice.

• Main Authors: Stuart D Dowall (Author), Victoria A Graham (Author), Emma Rayner (Author), Laura Hunter (Author), Barry Atkinson (Author), Geoff Pearson (Author), Mike Dennis (Author), Roger Hewson (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Zika virus (ZIKV) falls into two lineages: African (ZIKVAF) and Asian (ZIKVAS). These lineages have not been tested comprehensively in parallel for disease progression using an animal model system. Here, using the established type-I interferon receptor knockout (A129) mouse model, it is first demons...